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目的研究糖尿病并发急性脑梗死治疗采用氯吡格雷与阿司匹林同用法的临床效果。方法 90例糖尿病并发急性脑梗死患者,随机分为A组和B组,各45例。A组采用阿司匹林治疗,B组采用氯吡格雷与阿司匹林同用法治疗。比较两组患者糖尿病并发急性脑梗死治疗效果;不良反应发生率;治疗前后患者空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c)、神经功能缺损评分的差异。结果 B组患者糖尿病并发急性脑梗死治疗总有效率97.78%高于A组的82.22%,B组不良反应发生率4.44%低于A组的24.44%,差异有统计学意义(P<0.05)。治疗后,两组FBG、2 h PBG、Hb A1c、神经功能缺损评分优于治疗前,B组FBG、2 h PBG、Hb A1c、神经功能缺损评分改善优于A组,差异有统计学意义(P<0.05)。结论糖尿病并发急性脑梗死治疗采用氯吡格雷与阿司匹林同用法的临床效果确切,可有效改善患者血糖和神经功能,减少不良反应发生,安全有效,值得推广。
Objective To study the clinical effect of using clopidogrel and aspirin in the treatment of diabetes complicated with acute cerebral infarction. Methods Ninety patients with diabetes mellitus complicated with acute cerebral infarction were randomly divided into group A and group B, with 45 cases each. A group treated with aspirin, B group with clopidogrel and aspirin with the same treatment. The effect of treatment on acute cerebral infarction and diabetes mellitus was compared between the two groups. The difference of fasting blood glucose (FBG), 2 h PBG, Hb A1c and neurological deficit scores before and after treatment were compared between the two groups. . Results The total effective rate of diabetes mellitus complicated with acute cerebral infarction in group B was 97.78% higher than that in group A 82.22%. The incidence of adverse reactions in group B was 4.44% lower than that in group A 24.44%. There was significant difference (P <0.05). After treatment, the score of FBG, 2 h PBG, Hb A1c and neurological deficit in both groups was better than that of before treatment, FBG, 2 h PBG and Hb A1c in group B were better than those in group A, the difference was statistically significant ( P <0.05). Conclusion The clinical effect of using clopidogrel and aspirin in the treatment of diabetes mellitus complicated with acute cerebral infarction is exact. It can effectively improve the blood sugar and nerve function, reduce the occurrence of adverse reactions, and be safe and effective.