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目的：对比观察碱化布比卡因和非碱化布比卡因的临床效果及药代动力学。方法：选择ＡＳＡⅠ～Ⅱ级肩部或上肢手术患者１６例，随机分为两组：碱化组与对照组各８例，均用０．７５％布比卡因２ｍｇ／ｋｇ行肌间沟臂丛神经阻滞。结果：与对照组比，碱化组麻醉起效时间和阻滞完善时间短，镇痛时间长（Ｐ＜０．０５或０．０１）。碱化组最高血药浓度（Ｃｍａｘ）为０．９９７８±０．３１３０μｇ／ｍｌ，血浆药物浓度达到高峰的时间（Ｔｐｅａｋ）为２９．４３６３±５．８２２３ｍｉｎ；对照组Ｃｍａｘ为０．８８９８±０．２５７２μｇ／ｍｌ，Ｔｐｅａｋ为２９．３１５６±１１．１９９１ｍｉｎ（Ｐ＞０．０５）。结论：碱化布比卡因阻滞效果优于非碱化布比卡因；２ｍｇ／ｋｇ碱化布比卡因用于臂丛神经阻滞时，其血药浓度和峰值浓度均比用市售药高，但未达到中毒阈值
Objective: To compare the clinical effects and pharmacokinetics of alkalinized bupivacaine and non-alkalized bupivacaine. Methods: Sixteen ASA Ⅰ ~ Ⅱ grade shoulder or upper limb surgery patients were randomly divided into two groups: basilar group and control group, each of which was treated with 0.75% bupivacaine 2 mg / kg Plexus block. Results: Compared with the control group, the time to onset of anesthesia, the time to complete blockade and the duration of analgesia in the alkalosis group were longer (P <0.05 or 0.01). The maximum plasma concentration (Cmax) was 0.9978 ± 0.3130μg / ml in the alkalosis group and 29.4363 ± 5.8223min in the peak plasma drug concentration (Tpeak), and 0.8898 ± 0 in the control group. 2572 μg / ml, Tpeak was 29.3156 ± 11.1991min (P> 0.05). Conclusion: The effect of alkalinizing bupivacaine is better than that of non-alkalinizing bupivacaine. When 2mg / kg alkalinized bupivacaine is used for brachial plexus blockade, the plasma concentration and peak concentration are better than those of non-alkalinized bupivacaine High sales of drugs, but did not meet the poisoning threshold