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1946年Harrison首先用氯化钠、氯化钾加硷及葡萄糖溶液作口服补液,当时是用于脱水经静脉补液后的维持治疗或者用来预防婴儿肠炎初起时的脱水。这种最早的口服补液含碳水化合物3.3%,旨在减少蛋白质分解及防止酮体生成。以后,Philips等首次将口服补液用于水钠丢失特多的霍乱病,他们通过体外试验证明:小肠对葡萄糖的主动吸收耦联着钠离子运转;当糖浓度为2%或111毫分子/升(mmol/l)时,
In 1946 Harrison first with sodium chloride, potassium chloride plus alkaline and glucose solution for oral rehydration, was used for dehydration after intravenous rehydration maintenance treatment or to prevent dehydration of infantile enteritis early. This earliest oral rehydration solution contains 3.3% carbohydrate, aiming to reduce protein breakdown and prevent ketone body formation. Later, Philips et al. First used oral rehydration for water chloramphenicol-losing cholera patients. They demonstrated in vitro experiments that the small intestine actively coupled glucose to sodium ions; when the sugar concentration was 2% or 111 mmol / L (mmol / l)