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本研究以血清辜九酮含量为观察指标，以氟化钠为受试物，对接触不同剂量受试组的雄性Ｗｉｓｔａｒ鼠进行了血清睾九酮含量测定，并对某铝厂氟接触连续１２年以上的男性工人（３７例）进行了血清睾九酮含量的检测。测定方法为ＷＨＯ提供的放射免疫方法。结果表明，在大鼠接触剂量为０．７～１１．２ｍｇ／ｋｇ体重，工人长期接触氟浓度为２．４６～２．６ｍｇ／ｍ￣３的范围内，氟化物对反映雄性生殖系统内分泌机能的大鼠及人的血清睾丸酮含量均无明显影响。
In this study, serum guanone levels as the observation index, sodium fluoride as the test substance, the male Wistar rats exposed to different doses of the test group were measured serum testosterone content, and a continuous aluminum fluoride contact 12 Male workers over the age of 37 (37 cases) were tested for serum testosterone. Measurement method for the WHO radioimmunoassay. The results showed that in the exposure dose of 0.7 ~ 11.2mg / kg body weight in rats, long-term exposure to fluoride in the range of 2.46 ~ 2.6mg / m ~ 3, fluoride to reflect the male reproductive system endocrine function Of rats and human serum testosterone content had no significant effect.