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目的为探讨双白蛋白血症与恶性疾病之间的关系。方法采用家系调查。蛋白电泳分析和资料检索查新等方法，对一个双白蛋白血症家族进行了10年追踪研究。结果该家系直系三代查出7／14例双白蛋白阳性，其中2例死于恶性伴发病：1例伴MM；1例伴肝癌。资料检索发现国内从1976年至今正式发表的研究文章有十四篇17个家系，其中有四位研究者在不同地域先后检出4例双白蛋白血症者均伴发恶性血液病：2例同伴MM；2例同伴白血病。结论提示双白蛋白血症与恶性疾病（恶性血液病）的发生有密切关系。
Objective To investigate the relationship between dialbuminemia and malignant diseases. Methods Family surveys were used. Protein electrophoresis analysis and data search and new methods were used to conduct a 10-year follow-up study on a family of dialbuminemia. Results 7/14 cases of double albumin were detected in the immediate third generation of the family, and 2 cases died of malignant complications: 1 case with MM; 1 case with liver cancer. Data search found that 14 domestic and 17 family members have published research articles since 1976. Among them, four researchers have detected four cases of double albuminemia in different regions and were associated with hematological malignancies: 2 cases. Companion MM; 2 patients with leukemia. The results suggest that there is a close relationship between dialbuminemia and the occurrence of malignant disease (hematologic malignancy).