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观察小剂量5-Fu、DDP、CF联合化疗(生化调节疗法)治疗晚期消化道癌28例的疗效和毒副反应。5-Fu 350mg/(m~2·d)、DDP 6mg/(m~2·d)、CF 200mg/w静脉滴注,每周5天,4周为1周期,完成3个周期。总有效率为46.3%(13/28)、CR 1例、PR 12例、NC 9例、PD 6例。毒副反应主要为恶心呕吐和白细胞下降。发生率分别为21%和42%。毒副反应能耐受,无需中止化疗。体质功能状态提高20～30分。认为小剂量5-Fu持续滴注联合小剂量DDP治疗晚期消化道癌有良好的近期疗效,明显降低了毒副反应,是一个安全有效的方法。
To observe the curative effect and toxicity of 28 cases of advanced digestive tract cancer treated with low-dose 5-Fu, DDP and CF combined with chemotherapy (biochemical modulation therapy). 5-Fu 350mg / (m ~ 2 · d), DDP 6mg / (m ~ 2 · d), CF 200mg / w intravenous drip, 5 days a week, 4 weeks for 1 cycle, complete 3 cycles. The total effective rate was 46.3% (13/28), CR 1, PR 12, NC 9 and PD 6. The main side effects of nausea and vomiting and leukopenia. The incidence rates were 21% and 42% respectively. Toxicity can tolerate, without stopping the chemotherapy. Physical functional status increased by 20 to 30 points. That a small dose of 5-Fu continuous infusion of small doses of DDP combined with advanced gastrointestinal cancer has a good short-term efficacy, significantly reducing the toxicity, is a safe and effective method.