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目的观察帕罗西汀、丁螺环酮联合甲钴胺治疗功能性消化不良的临床疗效。方法 120例功能性消化不良伴有焦虑和/或抑郁状态的患者,按就诊时间以奇偶数法随机分为研究组和对照组,其中对照组予以口服莫沙必利、静脉应用奥美拉唑治疗,研究组采用帕罗西汀、丁螺环酮联合甲钴胺治疗,疗程4周。症状完全消失后随访3个月。结果研究组显效率为56.7%,有效率36.7%,总有效率93.3%;对照组显效率25.0%,有效率40.0%,总有效率65.0%。2组显效率及总有效率差异均有统计学意义(P均<0.01)。且不良反应轻微。结论帕罗西汀、丁螺环酮联合甲钴胺治疗功能性消化不良较传统治疗起效快,效果比较满意,值得临床推广使用。
Objective To observe the clinical efficacy of paroxetine and buspirone combined with mecobalamin in the treatment of functional dyspepsia. Methods One hundred and twenty patients with functional dyspepsia accompanied by anxiety and / or depression were randomly divided into study group and control group according to the time of visiting with the method of odd and even. The control group was orally given mosapride and the omeprazole Treatment, the study group with paroxetine, buspirone mecobalamin treatment, the course of 4 weeks. Follow-up 3 months after the symptoms disappeared completely. Results The effective rate of the study group was 56.7%, the effective rate was 36.7%, the total effective rate was 93.3%. The effective rate of the control group was 25.0%, the effective rate was 40.0% and the total effective rate was 65.0%. Significant difference between the two groups were significant (P all <0.01). And mild adverse reactions. Conclusion Paroxetine, buspirone combined with mecobalamin treatment of functional dysfunction than the traditional treatment of fast onset, the effect is satisfactory, it is worth promoting the use of the clinic.