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已酮可可碱(Pentoxifylline,PTX)是具有磷酸二酯酶抑制剂活性的甲基黄嘌呤类药物.经犬实验表明,PTX 能减轻内毒素诱导的肺血管蛋白渗出,并抑制肺内中性白细胞聚积,减轻败血症豚鼠的肺水肿.体外实验表明,PTX 还可阻止中性白细胞激活.为证实 PTX 保护作用的机制是直接作用于内皮细胞还是阻止中性白细胞激活,进行了以下研究.牛肺动脉内皮细胞在处死后数分钟内取出,放入无菌基础培养基(MEM)中培养,当传至第6代并长成单层时作为实验对象,在有或无人中性白细胞参
Pentoxifylline (PTX) is a methylxanthine with the activity of phosphodiesterase inhibitor.Experiment results show that PTX can attenuate endotoxin-induced pulmonary vascular protein exudation and inhibit intrapulmonary neutrality Leukocyte accumulation reduces pulmonary edema in septic mice Guinea Pigs Pulmonary Artery Pulmonary Artery Pulmonary Artery Pulmonary Artery Pulmonary Artery Pulmonary Artery Pulmonary Artery Pulmonary Artery Endothelial cells were removed within minutes after sacrifice and were cultured in sterile basal medium (MEM). When passaged to passage 6 and grown into a monolayer endothelial cells were used as experimental subjects in endothelial cells with or without neutrophil