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观察地特胰岛素联合二甲双胍治疗2型糖尿病的疗效及安全性。方法观察62例2型糖尿病患者应用地特胰岛素每日一次注射,联合口服二甲双胍12周,分别于治疗前后测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2小时血糖(2hPG),并观察低血糖事件。结果与治疗前比较,HbA1c、FPG、2hPG均有降低,有显著性差异(P<0.05);低血糖发生率低,为3.22%。结论地特胰岛素联合二甲双胍治疗对于初诊2型糖尿病患者安全有效。
To observe the efficacy and safety of detemir plus metformin in the treatment of type 2 diabetes mellitus. Methods Sixty-two patients with type 2 diabetes were treated with dextromethorphan once a day for 12 weeks. Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and postprandial blood glucose (2hPG) were measured before and after treatment. Observe hypoglycemic events. Results Compared with those before treatment, HbA1c, FPG and 2hPG decreased significantly (P <0.05), and the incidence of hypoglycemia was 3.22%. Conclusion The combination of insulin detemir and metformin is safe and effective for newly diagnosed type 2 diabetic patients.