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将156例糖尿病肾病Ⅲ期患者随机分为治疗组和对照组各78例。两组均采用饮食控制和糖尿病常规治疗。治疗组采用滋肾活血方治疗,对照组采用贝那普利片治疗,疗程12周。结果治疗组ICAM-1、CPR、UAER、血糖及中医症状较治疗前显著下降(P<0.05或P<0.01);与对照组比较ICAM-1、CPR、尿白蛋白排泄率(UAER)、血糖、血脂及中医症状改善明显优于对照组(P<0.01或P<0.05)。结论滋肾活血方能降低糖尿病肾病Ⅲ期患者的血脂,降低ICAM-1、CPR的低度,减少尿白蛋白的排出,减轻肾损害,改善肾功能。
A total of 156 diabetic patients with stage Ⅲ diabetic nephropathy were randomly divided into treatment group and control group, 78 cases each. Both groups were treated with diet control and routine diabetes. The treatment group was treated with Zishenhuoxue prescription, while the control group was treated with benazepril tablets for 12 weeks. Results Compared with the control group, ICAM-1, CPR, UAER, blood glucose and TCM symptoms in treatment group were significantly decreased (P <0.05 or P <0.01); Compared with control group, ICAM-1, CPR, urinary albumin excretion rate , Blood fat and TCM symptoms were significantly better than the control group (P <0.01 or P <0.05). Conclusion Zishenhuoxue Decoction can reduce the blood lipids in patients with stage Ⅲ diabetic nephropathy, reduce the ICAM-1, the low degree of CPR, reduce urinary albumin excretion, reduce renal damage and improve renal function.