rAAV/ABAD-DP-6His attenuates oxidative stress- induced injury of PC 12 cells

• 作 者: Mingyue Jia Mingyu Wang Yi Yan
• 机 构: DepartmentofNeurology,DepartmentofNeurology,RadioactiveMedicineSpecialty,DepartmentofBurnandPlasticS
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2014年5期
• 关键词: 氧化应激损伤 PC12细胞 超氧化物歧化酶活性 ATP水平 衰减 Β淀粉样蛋白 线粒体膜电位 神经保护作用 nerve regeneration neurod
• 基金项目: Acknowledgments： We thank Liu Y and Wang ZC from Jilin University in China for providing technical support, Yang X from Jilin Univeristy for offering plent/TRX-ABAD-DP-prepro plas- mid, Zhang T from U

Our previous studies have revealed that amyloid β(Aβ)-binding alcohol dehydrogenase(ABAD) decoy peptide antagonizes Aβ42-induced neurotoxicity. However, whether it improves oxidative stress injury remains unclear. In this study, a recombinant adenovirus c