论文部分内容阅读
国产阿克拉霉素A(aclacinomycin;ACM-A)能明显抑制体外培养小鼠白血病P_(388)和人体胃癌SGC-7901细胞的生长。在0.01 μg/ml浓度时能抑制65.4%的克隆形成,ED_(50)为0.0085μg/ml。ACM-A对白血病小鼠有显著治疗作用,延长小鼠生命时间143%,并有半数小鼠获得治疗。对Ehrlich腹水癌和肉瘤-180也有较强的抑制作用,对肉瘤-180的作用与adriamycin相似。ACM-A主要抑制~3H-TDR和。H-UR分别参人人体胃癌细胞的DNA和RNA;大剂量时对蛋白质合成也有影响。P_(388)细胞实验中证明ACM-A对DNA合成的抑制程度与adriamycin相似,低于daunomycin。
Domestic aclacinomycin (ACM-A) can significantly inhibit the growth of mouse leukemia P 388 and human gastric cancer SGC-7901 cells in vitro. At the concentration of 0.01 μg / ml, 65.4% of clonogenicity was inhibited with an ED 50 of 0.0085 μg / ml. ACM-A has a significant therapeutic effect on leukemia mice, prolongs the life time of mice by 143% and treats half of them. Ehrlich ascites carcinoma and sarcoma -180 also have a strong inhibitory effect on the sarcoma -180 and adriamycin similar. ACM-A mainly inhibits ~ 3H-TDR and. H-UR were involved in human gastric cancer cells DNA and RNA, respectively; high-dose also has an impact on protein synthesis. P_ (388) cells showed that ACM-A inhibited the DNA synthesis at a similar level to that of adriamycin and lower than that of daunomycin.