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目的:探讨美托洛尔联合卡托普利对2型糖尿病合并高血压患者血糖、血脂和血压水平的影响。方法:选取浦江县人民医院2008年3月至2011年3月收治的2型糖尿病合并高血压患者96例,均进行常规降血糖、调血脂治疗,根据不同的治疗方法将患者分为3组——卡托普利组(A组)30例,美托洛尔组(B组)33例,卡托普利联合美托洛尔组(C组)33例。观察3种不同的治疗方法对2型糖尿病合并高血压患者血糖、血压和血脂水平的影响。结果:3组患者治疗后血糖、血脂四项比较差异均无统计学意义(P>0.05)。3组血压和心率治疗后比较差异有统计学意义(P<0.05),卡托普利联合美托洛尔组(C组)血压和心率下降的程度更明显。结论:3种不同的治疗方案对血糖、血脂水平均无明显影响,均能有效降压,卡托普利联合美托洛尔具有协同降压作用,降压效果更明显。
Objective: To investigate the effects of metoprolol combined with captopril on blood glucose, blood lipid and blood pressure in type 2 diabetic patients with hypertension. Methods: Ninety-six patients with type 2 diabetes mellitus complicated with hypertension were selected from Pujiang County People’s Hospital from March 2008 to March 2011. All patients underwent regular hypoglycemic and lipid-lowering therapy. Patients were divided into three groups according to different treatment methods: - 30 cases of captopril group (group A), 33 cases of metoprolol group (group B) and 33 cases of captopril combined with metoprolol group (group C). To observe the effects of three different treatments on blood glucose, blood pressure and blood lipid in type 2 diabetic patients with hypertension. Results: There was no significant difference in blood glucose and blood lipid between the three groups after treatment (P> 0.05). There were significant differences in blood pressure and heart rate between the three groups after treatment (P <0.05), and the degree of decrease of blood pressure and heart rate was more obvious in the captopril combined with metoprolol group (C group). CONCLUSION: Three different treatment regimens have no significant effect on blood glucose and blood lipid levels, both of which are effective in lowering blood pressure. Captopril combined with metoprolol has a synergistic antihypertensive effect, and the antihypertensive effect is more obvious.