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分子杂交技术是现代流行病学的主要研究手段 ,它在追踪菌株的来源以及探讨造成不同地区流行的菌株之间的关系上有重要意义。核糖体 RNA的编码基因检测及多态性分析已广泛应用于分子流行病学的研究中 [1 ,2 ]。我们采用了 2 3sr RNA基因的 Southern杂交技术对不同来源、不同地区
Molecular hybridization is a major research tool in modern epidemiology. It is of great importance in tracing the origin of strains and exploring the relationships between strains that are endemic in different regions. Ribosomal RNA encoding gene testing and analysis of polymorphisms have been widely used in molecular epidemiological studies [1,2]. We used Southern hybridization of 2 3sr RNA genes to different sources and regions