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目的:探讨益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的临床疗效和安全性。方法:选择中山火炬开发区医院2012年6月-2016年2月收治的活动期轻中度溃疡性结肠炎患者90例,采用随机数字表法分组为观察组和对照组,各组为45例,对照组采用基础性治疗进行干预,观察组给予患者口服双歧杆菌乳杆菌三联活菌片联合使用康复新液对患者进行灌肠,观察和比较两组患者的治疗效果、疾病活动指数(DAI)变化和不良反应发生率。结果:与对照组(73.33%)对比,观察组治疗有效率(95.56%)明显更高(P<0.05)。与对照组对比,观察组治疗后疾病活动指数明显更低,差异有统计学意义(P<0.05);与治疗前对比,两组治疗后疾病活动指数明显降低,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益生菌联合康复新液对活动期轻中度溃疡性结肠炎的疗效显著,安全性良好,有利于改善临床症状,降低活动期溃疡性结肠炎的活动指数。
Objective: To investigate the clinical efficacy and safety of probiotics combined with rehabilitation complex in the treatment of mild to moderate ulcerative colitis. Methods: Ninety patients with active mild-to-moderate ulcerative colitis admitted to Zhongshan Torch Development Hospital from June 2012 to February 2016 were randomly divided into observation group (n = 45) and control group . The control group was treated with basic treatment. The observation group was given orally with Lactobacillus bifidum triple active viable tablets combined with Kangfuxinye to enema the patients. The therapeutic effect, disease activity index (DAI) Change and incidence of adverse reactions. Results: Compared with the control group (73.33%), the effective rate of the observation group (95.56%) was significantly higher (P <0.05). Compared with the control group, the index of disease activity in the observation group was significantly lower after treatment (P <0.05), and the index of disease activity was significantly lower after treatment in both groups (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Probiotics combined with Kangfuxin solution has obvious curative effect on active mild-to-moderate ulcerative colitis with good safety, which is helpful to improve clinical symptoms and reduce activity index of active ulcerative colitis.