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目的:观察联合吸入抗胆碱能药物和β2受体激动剂对哮喘患者夜间急性发作的疗效。方法:将伴有夜间症状的哮喘患者113例随机分成联合给药组和对照组,当患者夜间出现急性发作时,对照组单纯给予二羟丙茶碱静脉注射,联合给药组在此基础上同时给予抗胆碱能药物和β2受体激动剂联合雾化吸入,记录夜间急性发作症状缓解的时间。结果:联合给药组喘息的快速缓解率为66.7%,对照组的为39.0%,快速缓解率两组之间的差异具有统计学意义。另外联合给药组喘息缓解率为84.9%,对照组的为68.3%,两组喘息缓解率的差异也具有统计学意义。结论:抗胆碱能药物和β2受体激动剂联合雾化吸入不但能明显缩短夜间症状急性发作缓解所需的时间,并且也可以增加疗效。
OBJECTIVE: To observe the efficacy of combined inhaled anticholinergic drugs and β 2 agonists in patients with acute asthma at night. Methods: Thirty-one asthmatic patients with nocturnal symptoms were randomly divided into combined treatment group and control group. When the patient suffered an acute attack at night, the control group was given intravenous injection of dihydroxypropylamine alone. On the basis of this, At the same time given anticholinergic drugs and β2 receptor agonist combined with inhalation, record the time of the acute exacerbation of symptoms at night. Results: The rapid remission rate of asthma was 66.7% in the combination group and 39.0% in the control group, and the difference between the two groups was statistically significant. In addition, the rate of remission was 84.9% in the combination group and 68.3% in the control group. There was also a statistically significant difference between the two groups in the remission rate. CONCLUSIONS: The combination of anticholinergic drugs and β2 agonists in combination with nebulized inhalation can significantly shorten the time required for the relief of acute episodes of nocturnal symptoms and can also increase the efficacy.