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宫颈癌是世界范围内常见的妇科肿瘤之一,宫颈癌恶性程度高,严重危害人类健康。现已经明确宫颈癌发病率与乳头状病毒感染密切相关〔1〕,随着宫颈刮片技术和乳头状病毒疫苗的广泛运用,子宫癌发病率得到一定程度的抑制,但是子宫癌发病率仍然居高不下,因而明确子宫癌发病机制迫在眉睫。近年来对子宫颈癌遗传学和分子生物学研究的深入表明遗传在子宫颈癌的发生发展中起着不容忽视的作用〔2-3〕。细胞毒性T淋巴细胞相关分子4(CTLA-4)属于免疫
Cervical cancer is one of the most common gynecological cancers in the world. Cervical cancer is highly malignant and seriously endangers human health. It has been clear that the incidence of cervical cancer and papillomavirus infection is closely related to [1], with the cervical smears and HPV vaccine widely used, the incidence of uterine cancer has been a certain degree of inhibition, but the incidence of uterine cancer still Habitat High, so clear uterine cancer pathogenesis is imminent. In recent years, genetic and molecular biology of cervical cancer in-depth studies have shown that genetics in the occurrence and development of cervical cancer plays a role that can not be ignored 〔2-3〕. Cytotoxic T lymphocyte associated molecule 4 (CTLA-4) is immunogenic