论文部分内容阅读
目的研究托吡酯添加治疗难治性癫的疗效和安全性。方法以2008年8月-2009年11月在本院儿科就诊的31例难治性癫患儿为研究对象,原来托吡酯添加治疗使用的抗癫药物种类和剂量不变,采用托吡酯添加治疗,初始剂量从0.5～1.0mg.kg-1.d-1开始,每周增加0.5～1.0 mg.kg-1,目标剂量为4.0～8.0 mg.kg-1.d-1,根据癫控制情况调整托吡酯用量。随访3个月。结果患儿治疗12周后,总有效率为84.0%,其中控制5例,显效14例,有效7例,无效5例,无恶化病例。治疗8周、12周,总有效率与治疗4周比较明显提高(Pa<0.05)。发作类型中,治疗12周后简单局限性癫总有效率为75.0%,复杂局限性癫为88.8%,全面性发作为92.3%,继发性癫为50.0%。9例患儿在加量期出现不良反应,但不需特殊处理,除6例体质量下降外,其他症状自行消失。结论托吡酯添加治疗难治性癫是安全有效的。
Objective To study the efficacy and safety of topiramate in the treatment of refractory epilepsy. Methods From August 2008 to November 2009 in our hospital pediatric treatment of 31 cases of refractory epilepsy in children as the study object, the original addition of topiramate anti-epileptic drugs used in the treatment of the same types and doses, the use of topiramate added treatment , The initial dose from 0.5 ~ 1.0mg.kg-1.d-1, weekly increase 0.5 ~ 1.0 mg.kg-1, the target dose of 4.0 ~ 8.0 mg.kg-1.d-1, according to the epilepsy control Adjust the topiramate dosage. Follow up for 3 months. Results After 12 weeks of treatment, the total effective rate was 84.0%. Among them, 5 were controlled, 14 were markedly effective, 7 were effective, 5 were ineffective, and none were worse. After 8 and 12 weeks of treatment, the total effective rate was significantly higher than that of the 4-week treatment (Pa <0.05). In the seizure type, the total effective rate of simple and limited epilepsy was 75.0%, 88.8%, 92.3% and 50.0% respectively after 12 weeks of treatment. Nine cases of adverse reactions in the dosage period, but without special treatment, in addition to 6 cases of weight loss, the other symptoms disappear. Conclusion Topiramate added in the treatment of refractory epilepsy is safe and effective.