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目的 观察HCPT +CF +FUDR方案对大肠癌的临床疗效。方法 5 4例Dukes’D期大肠癌患者 ,CF每天 10 0mg ,第 1～ 5天静滴 :FUDR每天 30 0～ 40 0mg/m2 ,第 1～ 5天继CF后静滴 ;HCPT每天 6～ 8mg/m2 ,第 1～ 10天静滴。每 2 8天重复为 1周期 ,所有患者都接受 4～ 6个周期化疗。结果 CR 6例 (11 1% ) ,PR 2 3例 (42 6 % ) ,CR +PR 5 3 7% (2 9/5 4)。其主要毒副作用为骨髓抑制和消化道反应。结论 HCPT +CF +FUDR方案治疗晚期大肠癌有较好的疗效 ,不良反应能为绝大多数患者所耐受。
Objective To observe the clinical efficacy of HCPT + CF + FUDR regimen in colorectal cancer. Methods Forty-four patients with Dukes’D stage colorectal cancer were treated with 100 mg of CF per day. Intravenous drops of the first day to fifth day: FUDR was 300 to 400 mg/m2 per day. The first to fifth days were followed by intravenous infusion of CF; HCPT 6 to 6 per day. 8mg/m2, 1st to 10th days of intravenous infusion. Repeat every 1 8 cycles, all patients received 4 to 6 cycles of chemotherapy. Results CR was 6 (11 1%), PR 2 3 (42 6%), CR +PR 5 3 7% (2 9/5 4). Its main toxic side effects are myelosuppression and digestive tract reactions. Conclusion HCPT + CF + FUDR regimen is effective in treating advanced colorectal cancer. Adverse reactions can be tolerated by most patients.