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【目的】探讨血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)在热性惊厥(febrile sei-zuresi,FS)患儿发生发展过程中的病理生理学作用,并分析其与发作后脑电图(electroencephalogram,EEG)和智能发育的关系。【方法】采用酶联免疫吸附法测定FS患儿(n=73)、急性上呼吸道感染无FS患儿(n=51)、健康儿童(n=43)血清BDNF水平,EEG检测FS患儿脑电活动,发育量表评估患儿恢复后智能发育情况。【结果】FS组血清BDNF浓度均显著高于上感组和正常组(P<0.01);EEG异常组血清BDNF浓度均高于EEG正常组(P<0.01或<0.05),且EEG发作性异常有高度统计学意义。小儿发育商与血清BDNF无明显相关(P=0.144)。【结论】FS患儿血清BDNF浓度明显增加,可能参与了FS的发生和发展过程;BDNF有望作为评估惊厥后脑损伤敏感指标;小儿智能发育指数与血清BDNF无明显相关性。
【Objective】 To investigate the pathophysiological role of serum brain-derived neurotrophic factor (BDNF) in the development of children with febrile sei-zuresi (FS), and to analyze the relationship between brain-derived neurotrophic factor Relationship between electroencephalogram (EEG) and intelligent development. 【Methods】 The serum levels of BDNF in FS children (n = 73), FS children (n = 51) and healthy children (n = 43) were measured by enzyme-linked immunosorbent assay Electrical activity, developmental scale assessment of children with post-recovery intelligence development. 【Results】 Serum BDNF concentrations in FS group were significantly higher than those in normal group and control group (P <0.01). Serum BDNF levels in patients with abnormal EEG were higher than those in normal EEG group (P <0.01 or <0.05), and EEG abnormalities Have a high degree of statistical significance. There was no significant correlation between pediatric development and serum BDNF (P = 0.144). 【Conclusion】 The serum levels of BDNF in FS children were significantly increased, which may be involved in the occurrence and development of FS. BDNF is expected to be used as a sensitive index in evaluating brain injury after convulsion. There is no significant correlation between the index of children’s mental development and serum BDNF.