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【目的】了解海口地区儿童呼吸道九种非典型病原体病原感染情况、明确非典型性病原体分布特点。【方法】对2011年7月-2012年6月临床诊断为呼吸道感染的患儿,分为<1岁组、1～2岁组、2～3岁组、≥3岁组,应用间接免疫荧光法进行九种病原体血清IgM抗体联合检测,对阳性病例进行回顾性分析。【结果】非典型性病原体感染阳性率34.6%(417/1 202);混合感染阳性率4.58%(55/1 202)以(M-pneumoniae,MP)与其他病原体混合感染为主;九种病原体中,阳性率排前三位的是肺炎支原体MP(31.53%)、乙型流感病毒(influenza B virus,INFB)(5.41%)、合胞病毒(respiratory syncytial virus,RSV)(1.16%);Q热立克次体(coxiella urnetii,COX)、肺炎衣原体(chlamydia pneumoniae,CP)检出最少;4月份(农历春末3月)阳性率最高,为47.57%,冬春季总阳性率高于夏秋季;总阳性率随年龄增加而增高;<1岁患儿MP、RSV阳性率排前两位,1岁及以上患儿以MP、INFB阳性率排前两位;男女患儿MP阳性率,女性患儿高于男性。【结论】海口地区呼吸道感染患儿非典型病原体的阳性率、病原体构成、高发季节等有自己的区域特点。
【Objective】 To understand the pathogen infection of nine kinds of atypical pathogens in children’s respiratory tract in Haikou and to clarify the distribution characteristics of atypical pathogens. 【Methods】 The children with respiratory tract infection clinically diagnosed from July 2011 to June 2012 were divided into group <1 year, group 1 ~ 2, group 2 ~ 3, group 3 " Method for nine pathogen serum IgM antibody detection, the positive cases were analyzed retrospectively. 【Results】 The positive rate of SARS infection was 34.6% (417/1 202). The positive rate of mixed infection was 4.58% (55/1 202), with mixed infection of M-pneumoniae (MP) and other pathogens. The nine pathogens Among the top three positive cases, MP (31.53%), INFB (5.41%), respiratory syncytial virus (RSV) (1.16% The coxiella urnetii (COX) and chlamydia pneumoniae (CP) were detected the least. The highest positive rate was 47.57% in April (late spring of March), the total positive rate in winter and spring was higher than that in summer and autumn ; The positive rate of total positive rate increased with age; The positive rate of MP and RSV in children <1 year old was the top two, and the positive rate of MP and INFB was the top two in children 1 year old and above. The positive rate of MP in male and female children, female Children than men. 【Conclusions】 The positive rate of atypical pathogens in children with respiratory tract infection in Haikou area, the composition of pathogens, the season of high incidence have their own regional characteristics.