论文部分内容阅读
非酒精性脂肪肝病（ NAFLD）是以肝细胞脂肪变性和脂肪沉积为病理特征，但无过量饮酒史的临床综合征，目前NAFLD在国内外的发病率正呈明显上升趋势。胰岛素抵抗是多种代谢性疾病（如2型糖尿病、肥胖、高血压、血脂紊乱等）共同的发病基础，而很多代谢性疾病的发生与 NAFLD有关。而多项研究也都证实胰岛素抵抗与 NAFLD存在明显相关性，NAFLD可直接或间接地影响胰岛素信号通路。寻找NAFLD导致胰岛素抵抗的相关因素，探讨其发生、发展以及治疗的分子机制，可能将成为未来的研究方向。“,”Nonalcoholic fatty liver disease ( NAFLD ) is a clinical syndrome characterized by hepatic steatosis and fat deposition,without history of excessive drinking.The incidence of NAFLD is on the rise sig-nificantly both in China and abroad.Insulin resistance is a common reason of many kinds of metabolic disea-ses,such as type 2 diabetes mellitus,obesity,hypertension,dyslipidemia,and many metabolic diseases are associated with NAFLD.And a number of studies have confirmed that insulin resistance and NAFLD are correlated significantly, NAFLD can affect insulin signaling pathway directly or indirectly.Searching for the related factors of insulin resistance induced by NAFLD to explore the molecular mechanism of its occurrence , development and treatment, may be the future research direction.