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OBJECTIVE: Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out different tests to evaluate the effect of aqueous extract of Solanum xanthocarpum(SXE) in postmenopausal syndrome. METHODS: The study was carried out in bilaterally ovariectomized one-month-old Wistar rats(40–50 g). Bilaterally ovariectomized(OVX) Wistar rats were divided into four groups(n=6) receiving different treatments, consisting of a vehicle(distilled water), aqueous extract of Solanum xanthocarpum at two different doses(200 and 400 mg/kg) administered orally daily for 90 d and standard drug β estradiol at a dose of 1 mg/kg administered subcutaneously biweekly for 90 d. Estrogenic activity was assessed by vaginal cornifi cation, sexual behavior, serum estradiol and uterine weight to body weight ratio. Antiosteoporotic activity was assessed on the basis of biomechanical and biochemical parameters followed by histopathological studies, and antidepressant activity was assessed by forced swim test. RESULTS: SXE showed presence of steroids. At the dose of 200 mg/kg, it signifi cantly improved all the parameters of sexual behavior(P<0.01), caused vaginal cornifi cation, and increased serum estradiol and uterine weight(P<0.01). It also significantly improved all the parameters of bone strength as well as depression(P<0.01). Histopathology of bones confi rmed the above fi ndings. CONCLUSION: The study indicated that SXE may provide an effective treatment in the prevention of postmenopausal symptoms.
OBJECTIVE: Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out METHODS: evaluate the effect of aqueous extract of Solanum xanthocarpum (SXE) in postmenopausal syndrome. METHODS: The study was carried out in bilaterally ovariectomized one-month-old Wistar rats (40-50 g). Bilaterally ovariectomized (OVX) Wistar rats were divided into four groups (n = 6) receiving different treatments consisting of a vehicle (distilled water), aqueous extract of Solanum xanthocarpum at two different doses (200 and 400 mg / kg) administered orally daily for 90 days and standard drug β estradiol at a dose of 1 mg / kg administered subcutaneously biweekly for 90 d. Estrogenic activity was assessed by vaginal cornifi cation, sexual behavior, serum estradiol and uterine weigh t to body weight ratio. Antiosteoporotic activity was assessed on the basis of biomechanical and biochemical parameters followed by histopathological studies, and antidepressant activity was assessed by forced swim test. RESULTS: SXE showed presence of steroids. At the dose of 200 mg / kg, It also significantly improved all the parameters of sexual parameters (P <0.01), caused vaginal cornifi cation, and increased serum estradiol and uterine weight (P <0.01). It also significantly improved all the parameters of bone strength as well as depression <0.01). Histopathology of bones confi rmed the above fi ndings. CONCLUSION: The study indicated that SXE may provide an effective treatment in the prevention of postmenopausal symptoms.