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目的:明确5-HT1A受体是否参与吻侧无颗粒岛叶皮层(rostral agranular insular cortex,RAIC)介导的抗炎性持续性痛效应。方法:采用行为药理学实验方法观察RAIC内微量注射选择性5-HT1A受体激动剂和拮抗剂对福尔马林诱发的伤害性行为(缩足反应)的影响。结果:RAIC内微量注射选择性5-HT1A受体的激动剂8-OH-DPAT(5.0μg/0.5μl)明显抑制福尔马林诱发的大鼠缩足反应;向RAIC内提前5min预先微量注射5-HT1A受体拮抗剂NAN-190(10μg/0.5μl)则可拮抗8-OH-DPAT(5.0μg/0.5μl)对缩足反应的抑制效应;RAIC内单独注射NAN-190对福尔马林诱发的大鼠缩足反应没有影响。结论:5-HT1A受体参与RAIC介导的抗炎性持续性痛效应。
OBJECTIVE: To determine if 5-HT1A receptor is involved in the anti-inflammatory persistent pain effect mediated by rostral agranular insular cortex (RAIC). Methods: The behavioral pharmacology experiment was used to observe the effect of microinjection of selective 5-HT1A receptor agonists and antagonists on formalin-induced nociceptive responses (RA) in RAIC. RESULTS: Microinjection of selective 5-HT1A receptor agonist 8-OH-DPAT (5.0μg / 0.5μl) into RAIC markedly inhibited formalin-induced contractile responses in rats. Microinjection of microinjection 5-HT1A receptor antagonist NAN-190 (10μg / 0.5μl) antagonized the inhibitory effect of 8-OH-DPAT (5.0μg / 0.5μl) on the contractile response; injection of NAN- Lin induced rat contractile response has no effect. CONCLUSIONS: 5-HT1A receptors are involved in RAIC-mediated persistent anti-inflammatory analgesia.