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目的考察以介孔硅材料MCM41为载体对盐酸左氧氟沙星的吸附能力,为其载药及释放行为以及建立介孔硅药物传递系统奠定基础。方法以MCM41作为吸附的药物载体,利用N2吸附表征MCM41的比表面积和孔结构。利用红外光谱法表征MCM41的表面形貌。利用紫外分光光度法对不同温度、时间和pH下,MCM41对盐酸左氧氟沙星的吸附情况进行研究。结果MCM41比表面积大、孔隙结构发达、孔径分布集中在2~4 nm内,为典型介孔材料;MCM41对盐酸左氧氟沙星有较强的吸附载药能力。吸附等温线符合Langmuir吸附等温式;吸附过程发生迅速,2h可达到吸附平衡,吸附动力学研究结果表明吸附过程为准二级动力学过程;吸附热力学提示吸附是放热过程;在pH值5~8内吸附量最大。结论介孔硅材料MCM41有较高的药物吸附性能,具备制备成缓控释载体的潜力。
Objective To investigate the adsorption capacity of levofloxacin hydrochloride with mesoporous silica MCM41 as a carrier, which lays the foundation for its drug loading and release and the establishment of mesoporous silicon drug delivery system. Methods MCM41 was used as adsorbed drug carrier, and the specific surface area and pore structure of MCM41 were characterized by N2 adsorption. Surface Morphology Characterization of MCM41 by Infrared Spectroscopy. The adsorption of levofloxacin hydrochloride by MCM41 was studied by UV spectrophotometry at different temperature, time and pH. Results MCM41 had a large specific surface area and a well-developed pore structure. The pore size distribution of the MCM41 was typical mesoporous materials. The mesoporous material MCM41 had a strong adsorption capacity for levofloxacin hydrochloride. The adsorption isotherms fit the Langmuir adsorption isotherm. The adsorption process takes place rapidly and adsorption equilibrium can be reached after 2 hours. The adsorption kinetics results show that the adsorption process is quasi-second-order kinetics. Adsorption thermodynamics suggests that the adsorption is an exothermic process. At pH 5 ~ 8 the largest amount of adsorption. Conclusion The mesoporous silica material MCM41 has higher drug adsorption capacity and possesses the potential of being a controlled release carrier.