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目的检测类风湿关节炎患者及正常对照组人员血浆白介素26的浓度,比较类风湿关节炎组与正常对照组间白介素-26水平，分析类风湿关节炎患者白介素26水平与其类风湿因子、C-反应蛋白、血沉的相关性，探讨类风湿关节炎发病机制及疾病活动与血清中白介素-26水平的关系。方法 ELISA法分别测定56名类风湿关节炎患者和30名正常对照组人员血清中的白介素-26的浓度，常规实验室检测红细胞沉降率、C-反应蛋白、类风湿因子，分析白素-26水平与类风湿关节炎的发病和类风湿关节炎患者血清学指标之间的关系。结果①类风湿关节炎患者血清中白介素26水平为(321.425士291.594)pg/ml，正常对照组血清中白介素-26水平为(12.3542士8.2561)pg/ml，类风湿关节炎患者血清中白介素-26水平显著高于正常对照(t=-4.126p0.2)。结论活动期类风湿关节炎患者外周血中自介素-26水平明显高于正常对照组，但类风湿关节炎患者外周血中自介素-26水平与类风湿关节炎患者的类风湿因子、C-反应蛋白、血沉无明显相关性。白介素-26可能参与类风湿关节炎的病理发病过程，对类风湿性关节炎构成一个有前途的靶向治疗。“,”Objective To investigate the serum level of interleukin-26 of rheumatoid arthritis (RA)patients and normal controls,Comparison the interleukin-26 level between groups of rheumatoid arthritis and control group,Analysis of the relationship between interleukin-26 levels and rheumatoid factor,C-reactive protein,erythrocyte sedimentation rate relevance in rheumatoid arthritis patients,to explore the relationship between disease activity and serum levels of interleukin-26. Methods The serum level of interleukin-26(IL-26)in 56 patients with RA and in 30 normal control was measured by ELISA,routine laboratory testing erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),rheumatoid factor (RF),The correlations of the serum level of IL-26 between rheumatoid arthritis and normal person were analyzed;analyzing the relationship between the level of interleukin-26 and serum markers of rheumatoid arthritis patients. Results ①rheumatoid serum arthritis in interleukin 26 levels(321.425±291.594)pg/ml,normal control group,serum interleukin-26 level(12.3542±8.2561)pg/ml,rheumatoid serum of patients with arthritis in interleukin-26 levels were significantly higher than in normal controls ( =-4.126, 0.2). Conclusion The serum level of IL-26 in patients with RA was statistical y higher than the control group but It was not cor elated with rheumatoid factor, C-reactive protein,erythrocyte sedimentation rate.Pathological pathogenesis of IL-26 may be involved in rheumatoid arthritis,interleukin-26 may constitute a promising targeted therapy.