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作者研究了78例(男45例,女33例)脑膜炎球菌感染病人及10名正常人血清中巯基的活性(正常值为49.0±0.76单位)。病人组中,极重型20例,严重型47例,中等型11例。所有病人用青霉素治疗,20～30万单位/公斤/日,肌注,连用5～8天。测定结果:脑膜炎球菌感染病人的巯基活性明显降低,其程度取决于病期、临床类型、严重程度及有无并发症。在疾病极期,其活性最低。脑膜炎球菌菌血症并脑膜炎者,其活性比单纯菌血症或脑膜炎者都低(入院时分别为:28.6±1.4,32.8±1.5及33.5±1.2单位)。中等型病例其活性降低不显著,发病后9～14天
The authors studied the thiol activity in 78 patients (45 males and 33 females) with meningococcal infection and 10 normal controls (normalized 49.0 ± 0.76 units). In the patient group, 20 cases were extremely severe, 47 cases were severe and 11 cases were moderate. All patients with penicillin treatment, 20 to 300000 units / kg / day, intramuscularly, once every 5 to 8 days. The results: meningococcal infection in patients with significantly reduced activity of sulfhydryl, the extent depends on the stage of disease, clinical type, severity and presence or absence of complications. In the extreme disease, its activity is the lowest. Meningococcal bacteremia and meningitis were less active than those with mephitis or meningitis alone (28.6 ± 1.4, 32.8 ± 1.5, and 33.5 ± 1.2 units at admission, respectively). Moderate cases of its activity was not significantly reduced, after the onset of 9 to 14 days