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选择慢性心房颤动(简称房颤)病人28例,男12例,女16例,年龄19～69(平均45.5)岁,房颤持续时间6月～12年,平均4.5年。风湿性心脏病22例、冠心病4例、扩张型心肌病1例、特发性房颤1例。所有病例除外病窦综合征、房室传导阻滞、房颤心室率低于70次/分、QT间期大于0.43s.风湿活动、左房血栓及血钾低于4 mmol/L。用药前停用洋地黄2天,禁用其它抗心律失常药物。转复期间及停药后1天每日记录12导联心电图,查血钾。每次用药前观察血压和心电变化。首日先服0.1g试验量无异常反应,第1,2日分别用1.0g,3,4日用1.5g,5,6
28 patients with chronic atrial fibrillation (atrial fibrillation), 12 males and 16 females, aged 19 to 69 (average 45.5) years of age, atrial fibrillation duration of 6 months to 12 years, an average of 4.5 years. Rheumatic heart disease in 22 cases, 4 cases of coronary heart disease, dilated cardiomyopathy in 1 case, idiopathic atrial fibrillation in 1 case. In all cases except for sick sinus syndrome, atrioventricular block, atrial fibrillation ventricular rate of less than 70 beats / min, QT interval greater than 0.43s. Rheumatoid activity, left atrial thrombosis and serum potassium less than 4 mmol / L. Disable digitalis 2 days before treatment, disable other anti-arrhythmic drugs. During the recovery and withdrawal of 1 day daily record 12-lead ECG, check potassium. Observed before each medication blood pressure and ECG changes. The first day of first service 0.1g test no abnormal reaction, the 1st and 2nd, respectively, with 1.0g, 3,4 days with 1.5g, 5,6