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选择25例健康体检者为对照组,男性15例,女性10例,年龄40～70岁。73例原发性高血压(EH),符合WHO诊断标准,排除继发性高血压。男性40例,女性33例,年龄45～68岁。根据有无左室肥厚,分为高血压组29例、高心病组44例。按随机数字表方法分配病人为硝苯吡啶组39例,哌唑嗪组34例。两药均改型为胶囊,外观一致。硝苯吡啶5～10mg,2～3次/日,哌唑嗪0.5～1.5mg,2～3次/日,疗程4周。治疗前2周停服降压药。观察期间双盲法给药及检测指标,观察结束后由主管者对号分析。放射免疫法测定血浆心钠素(ANP)及内源性类洋地黄样物质
Twenty-five healthy subjects were selected as the control group, 15 males and 10 females, aged 40-70 years. 73 cases of essential hypertension (EH), in line with WHO diagnostic criteria, excluding secondary hypertension. 40 males and 33 females, aged 45 to 68 years. According to the presence or absence of left ventricular hypertrophy, divided into high blood pressure group 29 cases, high heart disease group 44 cases. According to the method of random number table, the patients were assigned to nifedipine group (n = 39) and prazosin group (n = 34). Both drugs are modified capsules, the same appearance. Nifedipine 5 ~ 10mg, 2 ~ 3 times / day, prazosin 0.5 ~ 1.5mg, 2 ~ 3 times / day, course of treatment for 4 weeks. Stop taking antihypertensive drugs 2 weeks before treatment. During the observation double-blind administration and detection of indicators, after the observation by the supervisor of the number analysis. Plasma atrial natriuretic peptide (ANP) and endogenous digitalis-like substances were determined by radioimmunoassay