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连翘苷是肺毒清颗粒中重要的有效成分,是质量控制的监测指标,本论文优化了肺毒清颗粒中连翘苷的水提取工艺并建立了测定连翘苷含量的HPLC方法。通过L9(34)正交试验优化水提取工艺,确定了肺毒清原药材的最佳水提工艺为用10倍量水煎煮3次,每次1h。采用正交设计优化的工艺提取肺毒清颗粒中的连翘苷,提取率高,工艺稳定可行。
Forsythin is an important active ingredient in the lung toxin granules and is a monitoring indicator of quality control. In this paper, the water extraction process of forsythin in the Pelton granules was optimized and a HPLC method was established for the determination of forsythin. Through orthogonal experiment L9 (34) to optimize the water extraction process, it was confirmed that the optimum water extraction process of PTP was 10 times boiling water for 3 times, each time for 1 hour. Orthogonal design optimization of the process of extraction of Pifendin particles, the extraction rate is high, the process is stable and feasible.