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目的 研究腹腔镜胆囊切除术对机体应 激反应的影响。方法 将70例胆囊炎、胆囊结石患者随机分成腹腔镜胆囊切除组(LC)和开腹胆囊切除组(OC)。术前和术后第1，3，5，7?!d采集外周静脉血，测定白细胞介素1β(IL-1β)，肿瘤坏死因子α(TNF-α)，白细胞介素6(IL-6)和C-反应蛋白(CRP)。结果 两组手术前后IL-1β和TNF-α均无明显差异(P>0.05)，两组间手术前后比较也无明显差异(P>0.05)；两组手术后IL-6第1?!d升至最高，与术前及术后第3，5，7?!d比较有高度显著差异(P0.05)，两组之间比较亦无显著差异(P>0.05)；两组手术后CRP第1，3，5?!d均较术前有明显升高(P0.05)。结论 LC对机体应激反应与OC相比没有明显差异。“,”Objective To investigate the systemic stress responses of laparoscopic cholecystectomy(LC). Methods Seventy patients with cholecystolithiasis were randomly divided into two groups: LC and open cholecystectomy(OC). Peripheral blood samples were obtained during the preoperative day and 1, 3, 5, 7 day after operation. Serum cytokines levels (TNF-α, IL-1β and IL-6) and C-reactive protein(CRP) were measured. Results Changes of TNF-α and IL-1β before or after surgery in both groups showed no significant difference(P>0.05). Serum concentrations of IL-6 and CRP after surgery in both groups were significantly higher than those before surgery(P0.05). Conclusions The systemic stress responses of LC have no significant difference comparing with OC.