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目的:探讨5-FU宫颈局部多点注射联合TP方案用于晚期宫颈癌新辅助化疗的疗效和安全性。方法:选择2007年10月～2012年3月住院治疗的60局部晚期宫颈癌患者,分为实验组与对照组,实验组38例给予5-FU局部多点联合TP方案术前新辅助化疗后手术,对照组22例给予TP方案后行手术治疗。对两组术后病理、毒副反应、临床疗效进行比较。结果:实验组患者CR、PR分别为(12,31.58%)、(21,55.26%),总有效率为(33,86.84%)。对照组患者CR、PR分别为(2,9.1%)、(11,50%),总有效率为(13,59.1%)。毒副反应两组相当,经对症处理后都能耐受。结论:5-FU宫颈局部多点注射联合TP方案进行术前新辅助化疗后患者最大肿瘤直径缩小明显,毒副反应并未明显增加,是一种安全有效的治疗方法。
Objective: To investigate the efficacy and safety of 5-FU cervical multi-point injection plus TP regimen in neoadjuvant chemotherapy for advanced cervical cancer. Methods: Sixty patients with locally advanced cervical cancer who were hospitalized from October 2007 to March 2012 were divided into experimental group and control group. 38 patients in experimental group were given 5-FU local multi-point combined TP regimen with neoadjuvant chemotherapy Surgery, control group, 22 cases given TP program after surgery. The two groups of postoperative pathology, toxicity, clinical efficacy were compared. Results: The CR and PR in the experimental group were (12,31.58%) and (21,55.26%), respectively. The total effective rate was (33,86.84%). The CR and PR in the control group were (2,9.1%) and (11,50%), respectively. The total effective rate was (13,59.1%). Toxic side effects of two groups quite, after symptomatic treatment can tolerate. CONCLUSION: The maximal tumor diameter of 5-FU cervical multifocal injection combined with TP regimen is significantly reduced and the toxicities and side effects are not significantly increased after neoadjuvant chemotherapy. It is a safe and effective treatment.