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Ovarian follicles produce two types of plasminogen activator (tPA and uPA), and their inhibitor(PAI). We have examined the interaction and regulation of these factors in ovarian intact follicles aswell as granulosa and theca-interstitial cells. The results show that only tPA, but not uPA, is regulated bythe gonadotropins and reaches maximum prior to ovulation. PAI is secreted mainly by theca-interstitialcells and is stimulated also by the gonadotropins. The formation of complexes between PA and PAI com-pletely blocks or decreases PA activity. It is suggested that the interaction between plasminogen activatorsand their inhibitor in the follicles may play a very important role in maintaining normal ovarian functionand the machnism of ovulation.
Ovarian follicles produce two types of plasminogen activator (tPA and uPA), and their inhibitor (PAI). We have examined the interaction and regulation of these factors in ovarian intact follicles aswell as granulosa and theca-interstitial cells. The results show that only tPA , but not uPA, is regulated by the gonadotropins and reached maximum prior to ovulation. PAI is secreted mainly by the ca-interstitial cells and is stimulated also by the gonadotropins. The formation of complexes between PA and PAI com-pletely blocks or decreases PA activity. It is suggested that the interaction between plasminogen activatorsand their inhibitor in the follicles may play a very important role in maintaining normal ovarian functionand the machnism of ovulation.