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蛋白质精氨酸甲基化是重要的细胞翻译后修饰方式,参与众多生命过程.精氨酸的甲基化修饰与糖代谢相关疾病如糖尿病、糖耐量异常密切相关.蛋白质精氨酸甲基化转移酶(proteinarginine methyltransferases,PRMTs)活性下降及表达异常是糖代谢疾病的重要发病基础.目前研究表明,PRMT1、PRMT4、PRMT5在糖代谢调节中均扮演重要角色,与糖代谢关键酶如磷酸烯醇式丙酮酸羧基激酶、葡萄糖6磷酸酶,胰岛素受体-胰岛素受体配体1-磷脂酰肌醇3激酶通道及其它通路密切相关.给予甲基化抑制剂MTA及siRNA干扰甲基化则可引发糖代谢紊乱,进而诱发糖代谢疾病.糖尿病药物罗格列酮、氨基胍与蛋白质精氨酸甲基化也有一定联系.深入研究蛋白质精氨酸甲基化与糖代谢调节之间的联系及机制,可为防治糖代谢疾病及相关并发症提供更多的理论依据.
Protein arginine methylation is an important post-translational modification of cells and participates in many life processes. Methylation of arginine is closely related to diseases related to glucose metabolism such as diabetes and impaired glucose tolerance. Protein arginine methylation PRMT1, PRMT4 and PRMT5 play an important role in the regulation of glucose metabolism, which are closely related to the key enzymes of glucose metabolism such as phosphoenol Pyruvate carboxykinase, glucose 6 phosphatase, insulin receptor - insulin receptor ligand 1-phosphatidylinositol 3 kinase pathway and other pathways are closely related to given methylation inhibitor MTA and siRNA interference methylation can be Triggering disorders of glucose metabolism, and then induce glucose metabolism disease.Radioglitazone, aminoguanidine diabetes mellitus and protein arginine methylation are also related.Depth of protein arginine methylation and regulation of glucose metabolism and Mechanism, for the prevention and treatment of glucose metabolism diseases and related complications provide more theoretical basis.