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乙酰螺旋霉素是大环内酯类抗生素,是螺旋霉素的半合成衍生物。螺旋霉素是一个含有A、B,C三个组份的混合物,当乙酰化后也是一个多组份的混合物。文献报导国内外乙酰螺旋霉素均由四种组份组成,但组份比例不同。因菌种生产工艺不同的乙酰螺旋霉素的组份,有明显差异,而日本产品以单乙酰螺旋霉素B为主。本文用反相高效液相色谱法,采用中国药品生物制品检定所提供的单乙酰螺旋霉素BC混合体,双乙酰螺旋霉素BC混合体为标准品,对江苏和浙江二个所标定的标准品,进行组份分析比较,将其结果报道如下:
Acetylspiramycin is a macrolide antibiotic, which is a semisynthetic derivative of spiramycin. Spiramycin is a mixture of three components A, B, C, also a multi-component mixture when acetylated. The literature reports that at home and abroad acetylspiramycin consists of four components, but the composition of different proportions. Due to the strain of acetylspiramycin different production process components, there are significant differences, while the Japanese products to monoacetyl spiramycin B-based. In this paper, reversed-phase high performance liquid chromatography, using the China Pharmaceutical and Biological Products provided by the acetylspiramycin BC mixture, biacetyl spiramycin BC mixture as a standard sample of Jiangsu and Zhejiang two standards Products, component analysis and comparison, the results reported as follows: