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抗癫痫药物的使用与骨折有关吗?近期报道称癫痫患者长期应用抗癫痫药物可增加骨折风险。Ahmad等对应用抗癫痫药物的癫痫患者(n=150,研究组)和未应用抗癫痫药物的非癫痫患者(n=506,对照组)进行横断面研究,记录并比较两组患者骨折与跌倒情况。结果显示,研究组患者更有可能发生脊柱骨折[优势比(OR)=3.92,可信区间(CI)=1.08～14.16,P=0.037)、锁骨部位骨折(OR=3.75,CI=1.24～11.34,P=0.019)和脚踝骨折(OR=2.34,CI=1.01～5.42,P=0.048),发生骨质疏松的风险增加(OR=4.62,CI=
Antiepileptic drugs and fracture related to the use of it? Recently reported that epilepsy patients with long-term use of antiepileptic drugs can increase the risk of fracture. Ahmad et al conducted a cross-sectional study of epilepsy patients with antiepileptic drugs (n = 150, study group) and non-epileptic patients without antiepileptic drugs (n = 506, control group), and recorded and compared fractures and falls Happening. The results showed that patients in the study group were more likely to have spinal fractures (OR = 3.92, CI = 1.08-14.16, P = 0.037), fractures of the clavicle (OR = 3.75, CI = 1.24-11.34 , P = 0.019) and ankle fractures (OR = 2.34, CI = 1.01-5.42, P = 0.048). The risk of osteoporosis increased (OR = 4.62, CI =