论文部分内容阅读
目的：探讨吸烟对正常人血浆降钙素基因相关肽(CGRP)的影响,分析CGRP的升高可能是吸烟者易患慢性阻塞性肺病(COPD)的诱发因素。方法:用放射免疫法对吸烟者、非吸烟者血浆CGRP进行检测。结果:A组 吸烟者组,吸烟指数>400支/年,烟龄>10年组血浆CGRP明显高于非吸烟组,差异有显著性。B组A组中选出部分人进行戒烟,戒烟时间>5年,测血浆CGRP明显低于继续吸烟者,差异有显著性。C组 吸烟者吸烟指数<50支/年,烟龄>10年者血浆CGRP高于非吸烟组,低于继续吸烟组,差异有显著性。结论:COPD是一种发病率高的呼吸系统疾病,吸烟是其发病的主要诱因,吸烟引起血浆CGRP升高可能是引起吸烟者易患COPD的机制之一。
Objective: To investigate the effects of smoking on plasma calcitonin gene-related peptide (CGRP) in normal subjects. To investigate whether elevated CGRP might be a predisposing factor for smokers with chronic obstructive pulmonary disease (COPD). Methods: Radioimmunoassay was used to detect plasma CGRP in smokers and non-smokers. Results: The plasma CGRP levels of smokers in group A were significantly higher than those in smoker group (> 400 cigarettes per year and> 10 years). In group B, some people were selected to quit smoking in Group A, smoking cessation time> 5 years, plasma CGRP was significantly lower than those who continued to smoke, the difference was significant. C group smoker smoking index <50 / year, smoking> 10 years of plasma CGRP higher than non-smoking group, lower than the continued smoking group, the difference was significant. Conclusion: COPD is a high incidence of respiratory diseases, smoking is the main cause of its occurrence. Smoking caused by elevated plasma CGRP may be one of the mechanisms that cause smokers susceptible to COPD.