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我科近10年来用多巴胺静滴,20例发生外漏致局部组织缺血坏死。男性16例,女性4例,平均年龄48岁。多巴胺浓度20～30mg%16例,40mg%4例,5例起水泡,15例局部坏死。13例为手背,5例为内踝,2例为前臂。讨论:多巴胺10mg%主要兴奋β受体,可解除微循环痉挛,达到纠正休克改善微循环.20mg%则兴奋α及β受体,若大于30mg%则主要兴奋α受体,引起末稍血管收缩,局部组织缺血缺氧,若外漏易致组织坏死。故要求使用多巴胺时以10mg%
Nearly 10 years my department with intravenous dopamine, 20 cases of local tissue leakage caused by external tissue necrosis. 16 males and 4 females, with an average age of 48 years. Dopamine concentration 20 ~ 30mg% 16 cases, 40mg% 4 cases, 5 cases blisters, 15 cases of local necrosis. 13 cases of the back of the hand, 5 cases of medial malleolus, 2 cases of forearm. Discussion: dopamine 10mg% main excitement β receptor, can relieve microcirculation spasm, to correct shock to improve microcirculation.20mg% are excited α and β receptors, if greater than 30mg% are mainly excited α receptor, causing terminal vasoconstriction Local tissue ischemia and hypoxia, if leakage can easily lead to tissue necrosis. It is required when using dopamine to 10mg%