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目的:观察前列灌肠液保留灌肠对大鼠急、慢性炎症的影响和对小鼠的镇痛作用。方法:分别取SD大鼠和昆明种小鼠,随机分成前列灌肠液高、中、低剂量组,阿司匹林组、空白对照(生理盐水)组5组,保留灌肠后观察角叉菜胶注射后引起的大鼠足肿胀度,大鼠腹股沟处植入棉球前后的肉芽肿重量,小鼠注射醋酸30min内出现扭体反应的次数,以及小鼠热板致痛阈值。结果:前列灌肠液高、中、低剂量均有抑制大鼠角叉菜胶足肿胀和大鼠棉球肉芽增生(P<0.05),其中给高剂量前列灌肠液时(剂量60mL/kg)有非常明星抑制作用(P<0.01),其抑制率与阿司匹林组无显著性差异(P>0.05)。前列腺灌肠水煎液低、中、高剂量均能减少小鼠扭体次数,并对热板致小鼠痛阈值均有明显提高作用(P<0.05),随剂量增加,镇痛效果越明显,呈现出明显的量效关系。结论:前列腺灌肠剂低、中、高剂量均具有抗菌消炎、镇痛等作用,高剂量时有非常明星的作用.
Objective: To observe the effect of forefront enema retention enema on acute and chronic inflammation in rats and analgesic effect on mice. Methods: SD rats and Kunming mice were randomly divided into five groups: high, medium and low dosage of forefront enema, aspirin group and blank control group (NS). After retention of enema, carrageenan injection was observed , The weight of granuloma in the groin before and after implantation of cotton balls in mice, the number of writhing reactions in mice injected with acetic acid within 30 min, and the pain threshold of hot plate in mice. Results: The high, middle and low doses of foregut enema inhibited rat carrageenan paw swelling and granulation tissue in rats (P <0.05). When given high dose forelimb liquid (dosage 60 mL / kg) Very star inhibitory effect (P <0.01), the inhibition rate and aspirin no significant difference (P> 0.05). Prostatic enema Decoction low, medium and high doses can reduce the number of writhing in mice, and hot plate induced pain threshold were significantly increased (P <0.05), with the dose increased, the more obvious analgesic effect, Showing a significant dose-effect relationship. Conclusions: The low, medium and high doses of prostatic enema have antibacterial, anti-inflammatory and analgesic effects, and have a very high star effect at high doses.