论文部分内容阅读
To investigate the dynamic interaction between antibody and antigen,Fan et al.rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room temperature.This study provides a straightforward,designable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve the understanding toward the design of the next-generation antibodies and vaccines for various biomedical applications.This work has been published online in Nature Communications on June 19,2020.