论文部分内容阅读
目的观察不同途径应用重组白细胞介素-2(rIL-2)对患者全身及肿瘤局部免疫的影响。方法对45例直肠癌患者给予肌肉或直肠粘膜下注射 rIL-2。结果直肠粘膜下应用 rIL-2不仅提高患者全身免疫功能,而且能激活肿瘤区域淋巴结天然杀伤细胞(natural killer,NK)和淋巴因子激活杀伤细胞(lym-phokine-activated killer,LAK)活性,促进淋巴结生发中心增生、浆细胞反应和窦组织细胞增生增强。结论直肠粘膜下注射 rIL-2是治疗直肠癌的一种安全有效的新方法。
Objective To observe the effects of recombinant interleukin-2 (rIL-2) on the systemic and local tumor immunity in patients. Methods 45 patients with rectal cancer were given intramuscular or rectal submucosal injection of rIL-2. Results The use of rIL-2 in rectal submucosa not only enhanced the systemic immune function of the patients, but also activated the activity of natural killer (NK) and lymphokine-activated killer (LAK) in the lymph nodes and promoted the lymph nodes. Germinal center hyperplasia, plasma cell reaction and sinusoidal cell proliferation were enhanced. Conclusion Rectal submucosal injection of rIL-2 is a safe and effective new method for the treatment of rectal cancer.