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目的探讨北方农村地区高血压患者血清总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)比值与缺血性脑卒中的关系。方法采用分层整群抽样方法于2004—2006年对辽宁省阜新县农村地区6412名(男性2805名,女性3607名)年龄≥35岁患原发性高血压病的常住人群(≥5年)进行流行病学调查和实验室检查,对血脂异常情况使用SPSS11.5软件进行统计分析。结果①缺血性脑卒中患者共330人。与非缺血性脑卒中组相比,具有较高的血压水平,TC及LDL-C水平均较高。②将TC/HDL-C比值分为<3.0、3.0～、3.5～、4.0～、≥4.5五组,随比值的增高,缺血性脑卒中的患病率显著增高。比值最高组的患病率是比值最低组的3.4倍。各组患缺血性脑卒中的危险性均高于参照组,除比值3.0～组外,各组OR值的增高均有统计学意义。结论缺血性脑卒中的患病率随TC/HDL-C比值的增高而升高。
Objective To investigate the relationship between serum total cholesterol (TC) / high density lipoprotein cholesterol (HDL-C) and ischemic stroke in rural hypertensive patients in North China. Methods The stratified cluster sampling method was used to measure the prevalence of essential hypertension (≥ 5 years) among 6412 rural residents (2805 males and 3607 females) aged 35 or older with essential hypertension in rural areas of Fuxin County, Liaoning Province during 2004-2006. Epidemiological investigation and laboratory tests were conducted to analyze the dyslipidemia using SPSS 11.5 software. Results ① A total of 330 ischemic stroke patients. Compared with non-ischemic stroke group, high blood pressure level, TC and LDL-C levels were higher. ② The TC / HDL-C ratio was divided into <3.0, 3.0 ~, 3.5 ~, 4.0 ~, ≥4.5 five groups, with the ratio increased, the prevalence of ischemic stroke was significantly higher. The highest odds ratio was 3.4 times the lowest odds ratio. The risk of ischemic stroke in each group were higher than the reference group, with the exception of the ratio of 3.0 ~ group, the OR of each group increased statistically significant. Conclusion The prevalence of ischemic stroke increased with the increase of TC / HDL-C ratio.