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目的:观察散结通络方治疗气滞痰结血瘀型甲状腺结节的临床效果,总结散结通络方对气滞痰结血瘀型患者的作用机制.方法:调取2013～2016年我院收治的120例甲状腺结节患者为研究对象,经中医辨证为气滞痰结血瘀型,所有患者随机分为对照组与观察组,对照组给予左旋甲状腺素片治疗,观察组给予散结通络方治疗,比较两组的治疗效果、结节大小变化情况及安全性.结果:观察组治疗效果总有效率以50.0％显著高于对照组21.7％ (x2=16.92,P＜ 0.001),两组治疗后的TPOAB、TGAB指标相比治疗前并未发生明显改变,且组间比较并无显著差异(t=0.12,P=0.904;t=O.15,P=0.875),观察组患者治疗后的最大直径、中医证候积分、恶变高危因素积分相比治疗前均明显减少且显著低于对照组(t=2.22,P=0.027;t=13.24,P＜0.001;t=4.80,P＜ 0.001),但对照组并无显著变化.结论:散结通络方治疗气滞痰结血瘀型甲状腺结节的效果确切,能有效改善患者的中医证候,降低恶变高危因素,防止疾病的进一步发展.“,”Objective:To study the clinical effect of Sanjie Tongluo Decoction for the treatment of stagnation of Qi and phlegm and blood stasis type of thyroid nodules,and to summarize the mechanism of Sanjie Tongluo Decoction on patients with Qi stagnation and blood stasis.Methods:In 120cases of thyroid nodules from 2013to 2016in our hospital as the research object,the syndrome of stagnation of phlegm and blood stasis type,all patients were randomly divided into controlled group and observation group,the controlled group received ievothyroxine treatment,the observation group was given Sanjie Tongluo Decoction treatment,and the safety of two groups were compared effect of nodule size change.Results:The effect of the observation group the total efficiency of 50％ was significantly higher than the controlled group which was 21.7％ (x2 =16.92,P＜0.001),TPOAB,TGAB of the two groups after treatment compared with before treatment did not change significantly,and there was no significant difference between the two groups (t =0.12,P =0.904;t =0.15,P =0.875),the maximum diameter and the observation of TCM syndrome symptoms,risk factors of malignant groups after treatment was better than before treatment,significantly reduced the integral and significantly lower than the controlled group (t=2.22,P=0.027;t=13.24,P＜0.001;t=4.80,P＜0.001),but the controlled group had no significant change.Conclusion:Using Sanjie Tongluo Decoction in the treatment of stagnation of Qi and phlegm and blood stasis type of thyroid nodules is effective,can effectively improve the patient's TCM syndrome,reduce the risk factors of malignant transformation,to prevent the further development of the disease.