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为监测抗痫药物浓度收集唾液,曾用小量柠檬酸放置舌上作催涎剂,这实际上干扰了EMIT QST法检测药物的浓度.一位使用乙琥胺患者的血浆药物浓度为1000μtmol/L,而两份唾液乙琥胺浓度是零,其唾液pH1.7,这首先归因于胃液返流.当药物用pH 2.0、3.0、4.0、5.0、6.0、7.0缓冲液稀释后检测时,发现样品的pH值对EMIT检测无影响.乙琥胺读数为零的唾液用蒸馏水稀释后,1∶4稀释得出药物浓度接近1000μmol/L.而1∶2稀释得出结果大大少于1000μmol/L,这说明有一种抑制因素存在,可能是做催涎剂的柠檬酸干扰EMIT QST检验.如柠檬酸浓度超过0.25
In order to monitor the anti-epileptic drug concentration of saliva collected, a small amount of citric acid was placed on the tongue as a salivating agent, which in fact interfered with the EMIT QST method to detect the concentration of the drug.Another patient using ethosuxc sodium plasma concentration of 1000μtmol / L, while two salivary ethylsuccinate concentrations were zero and their saliva pH was 1.7, which was first attributed to reflux of the gastric fluid.When the drug was tested for dilution with pH 2.0, 3.0, 4.0, 5.0, 6.0, 7.0 buffer, It was found that the pH value of the sample had no effect on the EMIT assay.Due to saliva dilution of distilled water, 1: 4 dilution of saliva showed that the concentration of drug was close to 1000μmol / L, and the result of 1: 2 dilution was much less than 1000μmol / L, indicating that there is a inhibitory factor may be salivary citrate interference EMIT QST test.If the citric acid concentration exceeds 0.25