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止痛药可粗分为作用于外周系统(外周)药物和作用于脊髓或大脑的(中枢)药物,本文仅对前一类药物加以讨论.新的“外周”止痛药的可能作用部位是干扰受损伤部位的痛觉传递或在痛觉到达脊髓前阻断其传导.由于这种药物不作用于CNS,只作用于外周,因此CNS的症状,如恶心、呼吸抑制和成瘾性等将减弱.最初的损伤通过在外周组织或内部器官释放致痛物质(Algogens)而引起疼痛,致痛物
Painkillers can be broadly divided into drugs that act on the peripheral system (peripheral) and drugs that act on the spinal cord or brain, and only the first class of drugs is discussed in this article. The possible sites of action for the new “peripheral” painkillers are Interferes with pain transmission at the site of injury or blocks its conduction before the pain reaches the spinal cord.As the drug acts on the periphery without acting on the CNS, CNS symptoms such as nausea, respiratory depression and addiction will diminish. The initial lesion causes pain by releasing Algogens in peripheral tissues or internal organs,