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目的报道一种新型免疫调节剂SYL927的合成方法。方法以联苯为起始原料,经酰化、缩合、还原、傅克酰化、成酯、环合、还原、碱水解、成盐共9步反应制得SYL927;其结构经1H-NMR、13C-NMR和MS谱确证。结果与结论改进了目标物的合成方法,使之更适合工业生产要求,总收率为14.4%。同时分析了环合反应副产物生成的原因,并对副产物进行了结构鉴定。
Objective To report the synthesis of a novel immunomodulator SYL927. Methods The biphenyl was used as the starting material to prepare SYL927 by acylation, condensation, reduction, Friedel-Crafts, esterification, cyclization, reduction, alkali hydrolysis and salt formation. The structure was characterized by 1H- 13C-NMR and MS spectra confirmed. Results and Conclusion The target synthesis method was improved to make it more suitable for industrial production with a total yield of 14.4%. At the same time, the reasons for the formation of by-products of the cyclization reaction were analyzed, and the by-products were identified.