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目的:探讨恩替卡韦治疗对乙型肝炎相关性肾炎患者对肝功能、肾功能的影响。方法:选择临床诊断乙型肝炎病毒相关性肾炎患者60例,随机分为常规保肝治疗对照组及恩替卡韦治疗组。观察肝功能、肾功能及乙型肝炎病毒DNA水平的变化。结果:与对照组相比,恩替卡韦治疗组血清HBVDNA水平及尿蛋白排出量明显下降,血清白蛋白水平明显升高,而对照组不明显(P<0.05)。结论:恩替卡韦治疗乙型肝炎病毒相关性肾炎患者安全有效。
Objective: To investigate the effects of entecavir treatment on liver function and renal function in patients with hepatitis B-related nephritis. Methods: Sixty patients with clinically diagnosed hepatitis B virus-associated nephritis were randomly divided into conventional hepatoprotective therapy group and entecavir treatment group. Observe the liver function, renal function and hepatitis B virus DNA level changes. Results: Compared with the control group, serum HBVDNA levels and urinary protein excretion were significantly decreased in patients treated with entecavir, serum albumin levels were significantly increased, while the control group was not significant (P <0.05). Conclusion: Entecavir is safe and effective in treating patients with hepatitis B virus associated nephritis.