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采用兔肠缺血－再灌注模型，观察能量制剂ＡＴＰ－ＭｇＣｌ_２和钙通道阻滞剂维拉帕米（ｖｅｒａｐａｍｉｌ）对缺血小肠能量代谢的保护。结果显示，应用ＡＴＰ－ＭｇＣｌ_２治疗可显著提高小肠组织缺血１ｈ后肠组织ＡＴＰ储存，ＡＴＰ－ＭｇＣｌ_２和ｖｅｒａｐａｍｉｌ都明显增加３０ｍｉｎ再灌注后肠组织ＡＴＰ的合成，防止再灌注期间组织细胞Ｃａ￣２＋浓度超负荷，减轻血浆乳酸水平。提示ＡＴＰ－ＭｇＣｌ_２和ｖｅｒａｐａｍｉｌ可改善缺血小肠的能量代谢，增强肠组织对抗缺血缺氧的能力。
Rabbit intestinal ischemia-reperfusion model was used to observe the energy metabolism of ATP-MgCl_2 and calcium channel blocker verapamil on the energy metabolism of ischemic small intestine. The results showed that the application of ATP-MgCl 2 could significantly increase the ATP content in the intestinal tissue 1h after ischemia, and both ATP-MgCl 2 and verapamil significantly increased the synthesis of ATP in the intestinal tissue after 30min of reperfusion, preventing Ca 2+ concentration in the tissue cells during reperfusion Overload, reduce plasma lactate levels. Tip ATP-MgCl_2 and verapamil can improve the energy metabolism of ischemic small intestine, and enhance the ability of intestinal tissue against ischemia and hypoxia.