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磷酸咯萘啶(Malanidinum;Malanidine)的化学名为[2-甲氧基-7-氯-10-(3′、5′-双四氢吡咯-1-次甲基-4′-羟苯基)-氨基苯并[b]-1,5萘啶]磷酸盐。本品为一苯并萘啶的衍生物,国内外至今未见报道,是我国创制的一新型抗疟药,为黄色至橙黄色结晶性粉末,无臭,味苦。经动物实验测得其 LD_(50)为1523.7mg/kg。主要用于杀灭裂殖体。临床证明该药抗疟疗效显著,作用迅速,毒性低,副反应少,疗程短,使用简便,对氯喹无交叉抗药性。给药途径多,能口服,肌注和静脉滴注,为一优于氯喹的新药。适用于治疗各种疟疾包括脑型疟及凶险型疟疾的危重病人。
The chemical name of Malanidinum Malanidine is [2-methoxy-7-chloro-10- (3 ’, 5’-bistetrahydropyrrole- 1 -methoxy-4’-hydroxyphenyl ) -aminobenzo [b] -1,5-naphthyridine] phosphate. This product is a derivative of benzanaphthalene, so far no reports at home and abroad, is a new antimalarial drug created in our country, yellow to orange crystalline powder, odorless, bitter taste. The animal experiments measured LD_ (50) was 1523.7mg / kg. Mainly used to kill schizonts. Clinically proven anti-malarial significant effect of the drug, rapid action, low toxicity, fewer side effects, short course, easy to use, chloroquine no cross-resistance. Routes of administration can be oral, intramuscular and intravenous drip, a new drug better than chloroquine. For the treatment of various malaria, including cerebral malaria and dangerous malaria in critically ill patients.