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麻醉性镇痛药常有一个耐受和成瘾性的问题,即连续多次给药后,其镇痛作用不如初次给药明显,甚至无效,但更严重的是还会产生精神甚至物质依赖性。因此,随着药物研究的进展以及新强效镇痛药的发现,药物的滥用和药瘾犯罪等社会问题的发生率也不断上升。因此,当发现某新药有镇痛作用后,便应当研究其有无耐受和成瘾性。目前,耐受和成瘾性的问题已引起临床和药学工作者的高度重视。机体产生耐受性的机理极为复杂,有的药物耐受性的产生是由于该药物在体内代谢的改变,有的是由
Narcotic analgesics often have a problem of tolerance and addiction, that is, after repeated administration, the analgesic effect is not as good as the first administration, or even invalid, but even more serious is the result of mental or even material dependence Sex. Therefore, with the progress of drug research and the discovery of new potent analgesics, the incidence of social problems such as drug abuse and drug addiction crime continues to rise. Therefore, when a new drug is found to have an analgesic effect, it should be investigated whether it has tolerance or addiction. At present, the problems of tolerance and addiction have drawn great attention from clinical and pharmacy workers. The mechanism by which the body produces tolerance is extremely complicated, and some drug resistance is caused by the metabolism of the drug in the body, and some by